Covid 12/24: We’re F***ed, It’s Over

A year ago, there were reports coming out of China about a new coronavirus. Various people were saying things about exponential growth and the inevitability of a new pandemic, and urging action be taken. The media told us it was nothing to worry about, right up until hospitals got overwhelmed and enough people started dying.

This past week, it likely happened again. 

A new strain of Covid-19 has emerged from southern England, along with a similar one in South Africa. The new strain has rapidly taken over the region, and all signs point to it being about 65% more infectious than the old one, albeit with large uncertainty and error bars around that. 

I give it a 70% chance that these reports are largely correct.

There is no plausible way that a Western country can sustain restrictions that can overcome that via anything other than widespread immunity. This would be the level required to previously cut new infections in half every week. And all that would do is stabilize the rate of new infections.

Like last time, the media is mostly assuring us that there is nothing to worry about, and not extrapolating exponential growth into the future.

Like last time, there are attempts to slow down travel, that are both not tight enough to plausibly work even if they were implemented soon enough, and also clearly not implemented soon enough.

Like last time, no one is responding with a rush to get us prepared for what is about to happen. There are no additional pushes to improve our ability to test, or our supplies of equipment, or to speed our vaccine efforts or distribute the vaccine more efficiently (in any sense), or to lift restrictions on useful private action.

Like last time, the actions urged upon us to contain spread clearly have little or no chance of actually doing that.

The first time, I made the mistake of not thinking hard enough early enough, or taking enough action. I also didn’t think through the implications, and didn’t do things like buying put options, even though it was obvious. This time, I want to not make those same mistakes. Let’s figure out what actually happens, then act upon it. 

We can’t be sure yet. I only give the new strain a 70% chance of being sufficiently more infectious than the old one that the scenario fully plays out here in America before we have a chance to vaccinate enough people. I am very willing to revise that probability as new data comes in, or based on changes in methods of projection, including projections of what people will decide to do in various scenarios.

What I do know is we can’t hide our heads in the sand again. Never again. When we have strong Bayesian evidence that something is happening, we need to work through that and act accordingly. Not say “there’s no proof” or “we don’t know anything yet.” This isn’t about proof via experiment, or ruling out all possible alternative explanations. This is about likelihood ratios and probabilities. And on that front, as far as I can tell, it doesn’t look good. Change my mind.

The short term outlook in America has clearly stabilized, with R0 close to 1, as the control system once again sets in. Cases and deaths (and test counts) aren’t moving much. We have a double whammy of holidays about to hit us in Christmas and New Year’s, but after that I expect the tide to turn until such time as we get whammied by a new more infectious strain.  

Instead of that being the final peak and things only improving after that, we now face a potential fourth wave, likely cresting between March and May, that could be sufficiently powerful to substantially overshoot herd immunity.

Let’s run the numbers.

The Numbers

Predictions

Last week’s prediction: 13.1% positive rate on 11.5 million tests, and an average of 2,850 deaths per day.

Results: 13.7% positive rate on 10.7 million tests, with an average of 2,677 deaths.

We didn’t test substantially more people than last week, and the positive test percentage didn’t fall much, and the death rate didn’t rise much. Everything in a holding pattern. Some of that could be pending Christmas issues. Fool me twice, and all that.

This next week is Christmas plus New Year’s, so reporting issues are inevitable. Another week for wide error bars.

Prediction: 13.6% positive rate on 10.1 million tests, and an average of 2,500 deaths per day.

Note that I expect the deaths decline, at least, to be about reporting rather than about actual numbers, which I don’t think will start to decline much for a bit longer.

Deaths

DateWESTMIDWESTSOUTHNORTHEAST
Oct 22-Oct 2889517012208612
Oct 29-Nov 495619772309613
Nov 5-Nov 11108927122535870
Nov 12-Nov 181255293428181127
Nov 19-Nov 251761416933961714
Nov 26-Dec 21628381427421939
Dec 3-Dec 92437550842862744
Dec 10-Dec 163278532443763541
Dec 17-Dec 233826515851313772

Death rates didn’t rise all that much due partly to the decline in the Midwest, but they are still up in the other three regions and substantially in the West and South. It seems clearly a few weeks too early to hit peak deaths based on when we had peak infections.

Going forward, the vaccine will start to be effective for those who get infected next week, so to the extent we are protecting residents of nursing homes, we’ll see that effect in the death rate start to be noticable in late January. I expect deaths to be in decline by then. 

Positive Test Percentages

PercentagesNortheastMidwestSouthWest
10/22 to 10/283.68%9.87%8.58%6.46%
10/29 to 11/44.28%12.79%8.86%7.04%
11/5 to 11/115.56%17.51%9.89%8.31%
11/12 to 11/186.99%18.90%11.64%10.66%
11/19 to 11/257.00%16.62%10.41%11.75%
11/26 to 12/28.38%17.90%12.45%12.79%
12/3 to 12/910.47%17.94%13.70%12.76%
12/10 to 12/1610.15%15.63%15.91%13.65%
12/17 to 12/239.88%14.65%15.78%13.82%

Quiet on all fronts. Midwest clearly in slow decline, looks like other regions also ready to follow, as soon as we get past the holidays. There’s also an overall one-time bump coming of unknown size, but after that we should be clear until the new English or South African strain becomes a problem. 

Positive Tests

DateWESTMIDWESTSOUTHNORTHEAST
Oct 22-Oct 289498318188115812357420
Oct 29-Nov 411268425291716709870166
Nov 5-Nov 11157495387071206380108581
Nov 12-Nov 18211222452265255637150724
Nov 19-Nov 25269230435688294230170595
Nov 26-Dec 2256629357102294734185087
Dec 3-Dec 9354397379823368596263886
Dec 10-Dec 16415220315304406353260863

Also, this seems like a nice graphic:

But it’s also potentially misleading, because the increased cases in the deep South are mostly increased testing. The California increase is largely real. It would make sense that California would be the place that has stalled its crisis for the longest, between not having cold weather and imposing draconian restrictions all year, and so perhaps it’s finally time for them to face the music.

Test Counts

DateUSA testsPositive %NY testsPositive %Cumulative Positives
Oct 15-Oct 216,461,0286.4%865,8901.2%2.52%
Oct 22-Oct 286,943,4707.5%890,1851.4%2.67%
Oct 29-Nov 47,349,6489.5%973,7771.6%2.89%
Nov 5-Nov 118,285,87810.7%1,059,5592.4%3.16%
Nov 12-Nov 189,033,62112.4%1,155,6702.9%3.50%
Nov 19-Nov 2510,415,39311.8%1,373,7512.9%3.87%
Nov 26-Dec 29,741,05711.7%1,287,0104.0%4.22%
Dec 3-Dec 910,458,64413.9%1,411,1424.9%4.66%
Dec 10-Dec 1610,694,84513.8%1,444,7254.9%5.11%
Dec 17-Dec 2310,710,35613.7%1,440,7705.1%5.56%

This is the silent scandal no one is talking about. Why are we no longer expanding testing? It seems clear now that our capacity hasn’t been expanding in December. It’s clear that demand greatly exceeds supply, and that more testing would be a huge help. When things were improving slowly, at least they were improving. Now it looks like we are stalled out, well short of where we need to be. Vaccinations are important, but until we get a lot farther along on those, so are tests.

Covid Machine Learning Projections

Machine learning projections say infections have been static since about November 25, which mostly matches the testing data. We can assume that the projections will keep saying similar things for the next two weeks. 

Their predicted total infected is up to 19.2% on December 9, stabilized at 623k new infections per day. The total is up from 17.9% on December 2. As a reminder, I consider these lower bound estimates. 

The immunity effects here compound fast. Even if you assume people get infected completely at random, going from 17.9% to 19.2% immune reduces R0 by 1.6%, which reduces infection levels by that much every five days or so, or 9% per month, and we’re introducing that effect permanently each week. After a month of this level of effect, you’ll see a 16% decline from newly immune people alone. After two months, infection levels would be cut in half.

Selection of who gets infected makes the effect bigger, and also we get to add vaccinations.

Of course, the control systems ensure it does not work that way, as people will notice things improving and take more risks, but it’s worth noting that things will start rapidly getting better if we can only hold onto our current levels of prevention, and let immunity from all sources do the job from there.

Europe

Going to use short-dated graphs to improve readability. If you want the longer view you can get it at OurWorldInData, or previous weekly Covid posts.

Sh

The positive test percentages chart is so incomplete and all over the place that I’m going to stop posting it, but you can go to the source if you still want it.

Deaths in Europe continue to run close to those in the United States, suggesting the Europeans are finding cases less often than we are, or have worse medical care or are worse at protecting vulnerable populations. 

Then there’s that United Kingdom graph going rapidly vertical in infections. Turns out, there’s a reason, and it’s not that they lifted their restrictions…

The English Strain

The big news this week is that England has identified a new strain of Covid-19 that is ‘up to 70% more infectious’. The new strain dominates in southern England, including London, and the graphs tell a rather clear story.

[TODO] [Add Chart of English infections here]

Oh no.

You’re probably wondering the same question I was when I read that, which is that we know that ‘up to’ means we’re not willing to commit to anything at all (did you know I am up to 15 feet tall? It’s true!), but what the hell does ‘70% more infectious’ mean?

It could mean a lot of different things. 

To me, there are two natural hypotheses for what it means.

One sensible definition of this is that 70% more people get infected each day, so it raises R0 by that percentage. If previously things were stable, 70% more infectious would cause infections to rise 70% each serial interval, which I’ve been approximating at about five days. So if it was this, things would about double each week.

Alternatively, it could mean that any given physical interaction was 70% more likely to infect you. This seems unlikely to be it, because how would anyone know what this value was, but it still makes at least some intuitive sense and has some practical value. So if before, if you went home for Christmas and someone was infected, you’d have a 10% chance of getting Covid-19, now that number is 17%. 

The difference between those two is that if you get exposed multiple times, you can only get infected once, so the first scenario is a bigger jump in cases than the second one. Depending on how much ‘overkill’ you think takes place when people get infected, the difference could be big or it could be small.

As a third option, it could mean any given exposure is effectively as if you were exposed to 70% more virus. Chance of catching the virus is non-linear with viral load, so in some ways this is a more than 70% increased risk (if previously load was below threshold to get infected, and now it isn’t), and in other ways it could be less once you get to the other end of the curve. This also changes the distribution of initial viral loads, in ways that might be good or bad for outcomes and death rates. If you are reliably getting higher initial loads, that’s bad. If you are getting infected despite low loads then, given that we know you’re infected, that’s good, perhaps quite good. 

What I definitely didn’t consider was the possibility that this was measuring the length of the doubling time because that’s not remotely a fixed number and using this doesn’t make any sense and arrrrrgh and then I saw this on this post:

What is still driving me crazy is that CellBioGuy presumed that this was what they meant. I mean, I certainly hope it is what they meant in terms of ‘that physical property of the world would kill less people’ but I can’t help but notice it would be completely insane in a way that even my model of predicted general insanity isn’t handling well. The model isn’t even handling the presumption by CellBioGuy very well here.

So it turns out that CellBioGuy was wrong here, and this refers to the sensible thing of “percent rise in infections each cycle” R0 thing:

(Do check out the rest of that comment by CellBioGuy anyway – even though the presumption in question turned out to be wrong, the rest of the comment has a lot of good gears-level details on various issues, but it’s too long to put here in full. I’d like to know how well the rest holds up.)

So on the plus side, statistics are being reported in a way that is relative sane. 

On the minus side, this seems rather like it can be summed up as: We’re fucked, it’s over.

This is estimated as a 65% increase in infectiousness. If we want to stabilize infections in an area that was previously stable we’d need what would previously have been an R0 of about 0.6. If you have an R0 of 0.6 that means you would have previously been cutting infections in half each week or so.

Does that sound like something any Western country could possibly accomplish from here? What would even trying to do that even look like? Is there any chance people would stand for what was necessary to do that?

And that’s only what it takes to get a holding pattern. 

Under such dire circumstances, a phase 4 lockdown has been invoked. What does that mean? Glad you asked, here are the guidelines

The missing restrictions that stick out are not shutting down houses of worship, and allowing people to move house. Also funerals can go up to 30 people, whereas weddings are capped at 6. Also ‘support groups’ can meet up to 15 people and I don’t see anything saying it needs to be outdoors. 

Whereas essentially any social contact of any kind is forbidden (e.g.: “You cannot meet people in a private garden, unless you live with them or have formed a support bubble with them”), your ‘bubble’ is highly restricted in its sizing, and you’re not allowed to be outside without a ‘reasonable excuse’ although those include groceries, going to the bank or exercising. 

So basically, if you’re outside where it’s safe, they’ll harass you and maybe worse. Whereas if you stay inside, technically it’s not allowed but in practice it’s a lot less likely anything happens to you, unless the anything in question is ‘you catch Covid-19.’ The rules are porous enough that they aren’t enforceable against the things that are risky but enforceable enough to shut down the relatively safe actions that keep people sane. And with weird exceptions for remarkably large indoor gatherings for certain events that are textbook superspreaders.

All of which is what our model expects to see, and none of which seems likely to be remotely sufficient if the new strain is as infectious as they estimate.

The strain has already been seen in several other countries. Flights between the United States and the United Kingdom have not been shut down. Many European countries are shutting down some travel, which will slow things down a bit, but headlines like this one…

…illustrate that slowing things down is all that’s being aimed at. Which is good, because it’s too late anyway. There would not be any drivers to test if this was a real attempt at containment.

If the estimate of 65% more infectious is correct: The strain doubles every week under conditions where other strains are stable.

My father sent me this video (24 min) that makes the case for all of this being mostly a nothingburger. Or, to be more precise, he says he has only low confidence instead of moderate confidence that the new strain is substantially more infectious, which therefore means don’t be concerned. Which is odd, since even low confidence in something this impactful should be a big deal! It points to the whole ‘nothing’s real until it is proven or at least until it is the default outcome’ philosophy that many people effectively use.

Note that he also suggests the new strain is likely to be less virulent, and make us less sick, which could also be part of why it’s more infectious. If so, that’s great news (I can think of a scenario where it is actually bad news, but it’s an unlikely corner case).

He also points out correctly that a lot of nations don’t do much sequencing, so we should assume the new variant can’t be contained to England at this point. Doesn’t mean we shouldn’t try in order to slow it down, but such efforts will still fail.

The video seems strong on the scientific details, and the speaker strikes me as an excellent explainer/teacher, which is why I’m willing to link to it.

 Alas, as is often the case with academics that are good at learning and explaining scientific things, the epistemology is bonkers. His core argument is: “You cannot use epidemiological data to prove a biological property.” With a side of Covid-19 being spread mostly by super-spreaders (true) and thus the new variant could be winning at random. 

All of which is not how knowledge or Bayes’ rule works. It’s not how any of this works.

There is a valid point here, of course. Relying solely on the numerical growth of the strain or of infections in England generally, without looking at the context, doesn’t provide that much evidence. There are often other explanations. And his points about mutation in and of itself being commonplace and mostly harmless are well taken.

That doesn’t change that evidence is evidence, and a likelihood ratio a likelihood ratio. Experiments are not some special class of thing that are the only way one can make predictions or assign probabilities, and it’s weird that people can be so good at academic scientific thinking while not understanding this, and in fact it seems that when we train people to do academic science we also train them to not think about other information and to be careful not to use Bayes’ rule and to ridicule anyone who tries to use non-academic information in order to know things. 

With that in mind, we look at the evidence and think about possible explanations, and mostly I find that there aren’t other plausible ones worth assigning much weight to.

Let’s start with those charts above. They aren’t quite this:

But then again, when you consider the context of England being under lockdown conditions that had previously turned the tide, and that have stabilized the situation elsewhere in Europe…

And combine it with the share of infections from the new strain from the earlier chart, and work out what those combine to imply…

This definitely does qualify under “hot damn, look at this chart.” This is a huge, dramatic increase in infections happening very quickly. A doubling in one week.

Note also that the warnings went out to the public on December 19. The out-of-sample data from the next few days strongly reinforce the hypothesis that we’re screwed.

The other plausible causes of such a rapid rise are not present. England didn’t suddenly relax its conditions this much. The law of large numbers is more than sufficient to make me very dismissive of ‘random chance via superspreader events’ as an explanation. How big are these superspreader events? 

If my understanding of the situation is correct, there is only one conclusion:

This variant cannot be stopped short of mass vaccinations. It is not going to be stopped short of mass vaccinations. 

All that is left is a holding action. Realistically, we can’t make enough of a dent to turn the tide of cases of the new strain until at least May. That’s about twenty weeks from now. That’s twenty doublings. So for every case that’s escaped to the United States so far, we can expect (does quick math) a million cases. Then another few doublings in June and July.

I do think we can do better than that, because it appears the tide is starting to turn now on the old strain, we’ll get a bunch of incremental help from increased immunity along the way, and control systems will set in. 

But mostly, it seems like if you have vaccines and people who don’t want to die, you might want to hurry. I’ll get back to gaming the scenario out in the conclusion section.

All I Want For Christmas is a Covid Vaccine

Track it here.

Or at Bloomberg here.

So, then, about that vaccine effort. How goes the distribution of the vaccine? Well (Twitter video link), funny story

From CNN:

It seems that Pfizer executives are sitting around baffled that they have millions of additional doses of vaccine, and those doses are sitting on shelves unused, with continuous risk of spoilage, while they help no one. We have confirmation that this is explicitly not holding back second doses, and is coming as a complete surprise to Pfizer.

As a reminder, using a few million additional doses will cut infections by about 1% compounding each week, if distributed at random. If used selectively, an extra few million can cause a double digit drop in the death rate a month out, due to how concentrated deaths are among the elderly.

Distinctly from the issue of vaccine going to waste, the estimates given to states were too high, for which (Twitter video link) the head of Operation Warp Speed has taken responsibility. Such admissions are so virtuous and unexpected that they are clear signs of competence and trustworthiness. I agree strongly with Alex Tabarrok here, and my esteem for those involved went way up rather than down. 

Oh, and also:

Versus:

So there’s that. While regular folk are told to cancel the holidays. Merry Christmas, suckers.

Still, CNN again:

If true, that would be two weeks behind schedule, but assuming all of this is on a different track than manufacturing, so long as the process doesn’t keep falling further behind, I guess it’s not actually so bad? That’s a big ‘so long as.’ But it’s a plausible one, as initial difficulties don’t have to translate into difficulties once things are running and it’s not Christmas. 

Then there’s the issue of that second dose. The science behind why you need two doses is strong and makes sense, except for the little matter of the data. It’s clear that the first dose alone is much more than half as effective as two, and we don’t have enough doses. And the first thing I asked when I saw that result was something that is once again being pointed out. Booster shots do not have to be given two weeks after the first shot. The measles booster comes a year later. Multiple sources confirm that there is no reason to expect a six-months-later second dose to be any less effective a booster. 

We are mostly wasting an entire half of our vaccine supply by dosing exactly the worst people with it – the people who got the first dose. I can see double dosing those in nursing homes anyway, because they’re 1% of the population and over a third of deaths, so even a small additional boost is still worthwhile, and their immune systems are weak so it’s reasonable to worry the first dose alone won’t get the job done there. But beyond that, there’s no excuse I can see beyond saying the rules are the rules.

Here’s where we are, it seems:

Doses that arrive on July 31 are not doses I expect to prevent many infections. And this total does not leave much margin for error, we barely have enough doses if we don’t use AstraZeneca and insist on everyone getting two shots.

How goes the vaccine quest elsewhere? 

In Germany, not so well

A real case can be made that, given our inability to do suppression properly, a Western government’s policy ends up mostly coming down to their effect on the vaccination schedule. Did they advance vaccine research? 

On those fronts, we come out well ahead of the European Union. Does anything else matter by comparison? And how did we manage to do that? 

Casey Mulligan reminds us that one of the things Trump has been doing for a while is getting the FDA to kill less people by speeding up and streamlining its processes. So when the time came for Operation Warp Speed, the concept was shovel ready. The “experts” all said eighteen months minimum and the “experts” got ignored. We certainly could have pushed much harder much faster, even given initial conditions. I’m not going to stop pointing that out. The decision to balk at buying extra doses might be the worst single decision of the last four years, of any kind. But when I model alternative administrations, from either tribe, I model a much slower vaccine effort. When we reach the end, it’s not clear that won’t matter more than every other decision combined. 

In England, it seems they are going to be testing a vaccine grown using tobacco plants? Approval to begin trials is in. This seems like a great illustration of our regulatory state, because you can’t take the life-saving vaccine they grow with the tobacco plants, but you can take the tobacco in your pipe and smoke it even though we know it kills you. Okay, then.

Theoretical Vaccine Auction

If you want to properly allocate a scarce resource like a vaccine, obviously you use an auction. I said it last week, people righteously said that things are not worth to the customer what the customer will pay for them because poor people have less money than rich people, and no, sorry, that’s not how this works, that’s not how any of this works.

The good news for those who disagree is that there is not the slightest danger of any attempt at an efficient allocation of the vaccine.  

Externalities, on the other hand, are definitely real. To the extent that they are different for different people, we should take that into account. In theory, an auction can do that because others can subsidize the bids of those whose vaccination is beneficial to them. In a first best situation lots of people would subsidize lots of others near them and the government at various levels would also supplement bids, but presumably people mostly won’t get such acts together and it won’t happen except highly locally, inside families and corporations. 

My guess is that for all the talk of externalities, they’re not that different for different people other than those who were previously being irresponsible, and subsidizing them for that seems like it has some large moral hazard issues plus the worst offenders probably already had it. The exception would be those that provide a lot of value if they can expose themselves to the virus that they couldn’t otherwise, but are not being paid for that service enough to place the bids themselves. Health care workers in hospitals likely quality, but you can fix that if you subsidize the hospital to bid for them, and generally that class of solution seems like it should work.

Thus, the obvious solution of “N-lot, pay N+1th-highest-bid auction that repeats every so often” seems like it’s just correct on first principles, and then once you run the first one likely you can slowly reduce price to keep supply and demand balanced without having to go through all the trouble of more auctions? 

So that’s not that interesting a paper and also it’s about four lines long, so it was odd when I followed a Marginal Revolution link to this paper about how to auction off the vaccine only to find a much longer paper.

Which goes on to suggest this:

Which is exactly why no one wants to participate in auctions or read economics papers. I believe that the paper’s approach boils down to “everyone writes down how much they value each person getting the vaccine at each possible point in time, drawing that curve for everyone” and then the auctioneer solves for the best possible solution that maximizes surplus, and everyone pays the marginal cost imposed on others behind them, as measured by how much they don’t want to wait one more slot to get their vaccine.

Which, I mean sure, that’s technically correct of course, the best kind of correct, but it’s also making my brain hurt reading it and that’s despite intuitively knowing the answer the moment the question was asked. No one is going to want to think about let alone write down full utility curves, the practical cost would be enormous. 

And getting people in the wrong spot in line by a little bit is at worst a small mistake, and also not that meaningful given the logistics of vaccine administration. The vaccine is not exactly being teleported around.

Thus, I’m pretty sure in practice this reduces to ‘find the price that mostly clears the market and charge that price, then adjust it to keep clearing the market.’ The whole thing where others can bid on your behalf is how ‘people can buy things with dollars’ works already.  

In response to the people saying ‘but poor people are poor and rich people are rich, you bastards’ they say the following:

This is, essentially, distribute a valuable asset according to politics, then allow trade. Which is a worse version of full free trade, since it involves political reallocation of wealth and (as noted by Myerson) results in a lot of profitable trades not happening because of various frictions, and also makes people feel bad about not selling their vaccine dose and also about selling their vaccine dose, because choices are bad. It seems obviously better than allocating via politics alone, since most of the trades that happen will be hugely profitable to both sides – the person selling will get a payment much, much bigger than they’d have found necessary, and the person buying will pay much, much less than the amount they value the vaccine. The ZOPA (zone of possible agreement) here is mostly huge. I have a hard time imagining that choices being bad overcomes that.

What I personally would love is a form of abstract that is “the paper that we would have written if we were only trying to get the central point across and didn’t care about formal anything at all.” Not quite You Have About Five Words (I keep thinking the ‘have’ is ‘get’ and having to correct myself, maybe the title should change) but mostly not that much more than that. A one-page Econ 101 cheat sheet can cover actual everything the class teaches, and most economics papers have at most one paragraph of actual information.

Here, it sure seems like the whole paper boils down to “Standard auction theory applies here.”

It usually does. 

This, for example, is a great use case. Not Covid-19 related or in any way essential, but pretty great

Another modest proposal is to fix the prices and then let people pay them, skipping over the auction as such, so we know we can raise $50 billion dollars for vaccine production and distribution (and motivation, shall we say) by letting a few people skip the line. That makes it easy to see it’s an absurdly good deal, but also either wouldn’t get enough takers or is leaving a lot of money on the table, in exchange for being easy to think about. 

Also, that post points out something that seems important. What could be a better way to motivate people wanting the vaccine, than to show our richest, most famous and most powerful people paying really big bucks to get the shot a few months sooner? 

The Chosen Alternative To That Auction

Meanwhile in vaccine prioritization via politics and power might occasionally have some issues news (Twitter video link to protesters protesting during meeting, and thread):

If I am interpreting this correctly, those with power used politics to get vaccinated first, ahead of nurses and residents. Residents, of course, are indentured servants giving four years of work under terrible conditions with hugely below market pay in exchange for the right to join a monopolistic guild that enforces scarcity of health care provision via government restrictions on supply of residences and slots in medical school. 

This is exactly how political distributions of goods always go, except that this time it was a really bad look to give administrators in offices the vaccine before doctors who were actually treating Covid-19 patients. That’s what “The list created by the algorithm was supposed to be vetted” means here, that they were supposed to do a check to make sure their naked appropriation of vaccine had some plausible deniability attached at some level, whereas it turned out it didn’t.

But of course, as the thread points out, blaming ‘the algorithm’ or saying ‘there are problems with the algorithm’ is the obvious nonsense. Yes, there was a ‘problem with the algorithm’ and the ‘problem’ was ‘the people with power over the contents of the algorithm gave themselves top priority.’ This wasn’t some complex calculation. It didn’t involve machine learning. The result wasn’t surprising to anyone who came up with the criteria. The criteria was giving resources to the powerful rather than the powerless, via deeming them more ‘important’ or ‘vital’ or something. 


This time, thankfully, they got caught. Yet they still got their vaccine shots. 

Thus, this apology is the height of hypocrisy:

Did not anticipate, you say. Equitable distribution, you say. In case you ever wonder what equitable distribution means when those with power say it, now you know.

You gotta love the line “Though our intent was to ensure the development of an ethical process, we recognize that the plan has significant gaps.” 

There’s also this:

Also, I’m not going to link to any of the sources for this (to avoid heat vs. light and toxoplasma of rage issues, among other reasons), or offer a hot take on it, but there are a lot of “experts” and “ethicists” who have stated outright that we shouldn’t prioritize older people over younger people because older people are disproportionately white, so giving vaccine priority to the people most likely to die from Covid-19 is racist. 

It is unclear to me to what extent this is driving policy decisions, but it seems like it came close to happening, with the CDC only reversing after a public outcry. The mayor of New York has endorsed this perspective explicitly.  

So. Yeah. 


But congratulations to Texas, among others (via CNBC):

Face Saving

Kerry gets it, a thread I will post here in full:

The government anticipates that people will not Act Responsibly on Christmas, and thus is pre-emptively punishing them in order to send a message. 

What’s interesting is her proposal that we can understand such acts by the Very Serious People as being primarily about face.

This reaches many of the same conclusions and makes many of the same predictions as many of the models and gears I’ve been using, but seems importantly different in ways that require more attention. These dynamics have been mostly left out of my models, and that seems like it might have been a mistake. 

I am going to think more about whether it makes sense to incorporate such dynamics more centrally. 

Quest for the Test

The good news is a $5 paper test strip has been approved by the FDA for home use. Of course, doing so legally will require an additional $25 so a digital MD service can watch you do it, which also means all sorts of coordination problems  and activation energy and having to be observed by medical people silently judging you. Because of the need to beware trivial inconveniences it seems like the additional costs will be hugely destructive of the potential value here, although massive value should still remain.

Perhaps the next one will do better? As usual there’s claims it is coming Real Soon Now:

Alas I expect that last mile to find a way to at least inflict a lot of damage, even if cleared.

Whereas this plan from Canada seems awesome, taking the methods of continuous rapid testing that worked in some universities and applying them more generally to businesses that value being open. 

And that’s this plan from Wisconsin:

Free testing on demand, sample collection at home, even if it isn’t rapid, and even if they require a zoom call during the sample collection. And you need an email for each of your children, even if they’re two weeks old. Still. That’s not bad!

A sign they do not understand the proper goal of testing is that they don’t grok that people might want to do this periodically without any particular reasons to worry:

Another sign is, look for the mysteriously missing question on this FAQ list:

Oh yeah, that question. How long until I get my test results?

Good question!

In Other News

This analysis of how Covid-19 spreads seems excellent as far as I can tell, making a strong case that it’s mostly or entirely aerosol transmission, and that this fits the observed data fine, thanks. People I respect led me to it and also had the same take. If there’s anything wrong here, please speak up.

CDC issues the following guidelines and it only took until (checks calendar) December 21:

Any further questions? Never fear, they have an FAQ

Also, yes, air ducts can almost certainly spread the virus, and six feet is not a magic number.

If you’re looking for treatments, this Quora response seems to be a real attempt at providing guidelines one could use. As usual I’m going to tread lightly on the treatment side and not take a stand.

Not a metaphor: Yes, you literally have to report as a ‘severe adverse event’ requiring investigation when someone in your vaccine trial is struck by lightning:

Official in Buffalo gives press conference announcing 60 people died, reporters only ask questions about the division champion Buffalo Bills. Official then tells them to ‘get their priorities straight’ but their priorities are already quite straight. The reporters know there’s a lot of deaths, and a lot of Covid-19, but what is the actionable information about that, that the official could tell them, that they don’t already know? What impacts people’s lives? The team could be in an unknown amount of trouble, and that matters to people in Buffalo. Whereas barring a change in policy that would have already been announced, they know exactly how screwed they are personally, and what they have to do. The true objection here is that when people are dying it’s wrong to not waste one’s time showing one’s concern about that and instead care about “trivial” things like the thing most or at least many people in Buffalo have cared most about the last few months. Or years.

Is using the bathroom essential? Second worst person Mayor De Blasio’s administration decided that it was not:

When a predictable uproar followed, he laid the blame on actual worst person Governor Andrew Cuomo, and requested that they gracefully allow New Yorkers to use indoor plumbing, a request that it seems has been granted:

Also, among other rules, employees cannot drink alcohol under any circumstances, which seems rather cruel except for the part where they never enforce it. Right now I bet a lot of them could use a drink.

This seems to be what you get when you shut everything down for months and months on end:

Why It Took So Long for the Army to Make Masks. The army masks are cloth masks with the right color scheme and symbols. That’s it. They are now getting around to being able to make them. The money quote for me is this:

According to the Army:

The CCFC was designed, developed, and produced along an expedited timeline. It normally takes 18–24 months for DLA (Defense Logistics Agency) to have the item available for order once the technical description, design, and components are approved and submitted. The CCFC, from inception to issuance, is slated to take less than one year.

The army is bragging that they figured out how to make masks this fast.

If there is a war, perhaps someone should tell the army. Seems like information they would want to know.

No news in the latest comparison of the Pfizer and Moderna vaccines. Bottom line is, they’re the same, except Moderna’s logistics are better. 

Would I accept the Chinese vaccine? I mean, yes, I still think it’s better than nothing, but wow do they continue to be bad at science in a way that seems almost intentional:

I know you think you’re helping but maybe just send paid time off?: 

Not Covid, rather about hearing aids, once more with feeling: FDA Delenda Est.

Not Covid: MIRI gives its yearly research update. Disappointing to learn that research they couldn’t talk about didn’t pan out, and also disappointing that they still can’t talk about what it was, especially given hopes that the ideas might still have merit. Good to know they are willing to pivot to other different things and aren’t going to either keep going down a known blind alley or joining the gradient descent crowd. Also great to hear they are considering fleeing Berkeley, which I strongly endorse doing almost no matter the destination. Would love to do some coordination on that, but I’d definitely settle for the New Hampshire scenario, which I think would greatly enhance their ability to think.

Also not Covid, Other LessWrong news: The 2018 review is ongoing, but not many reviews are being written. I’d encourage those who qualify to help change that. I’m especially curious to hear people’s takes on my nominated posts.

Universal, the cult of the expert as explained by the Washington Post freelancer system:

America’s finest news source weighs in on what snow days are for. And a reminder via Marginal Revolution, from the last pandemic, of what school is for and what happens when you cancel it.

What Happens Now?

There are many unknowns that have a dramatic effect on the path forward, and how the endgame plays out. 

A few big ones dominate.

I do not see it as plausible that the new strain is confined to England. It has already been seen in several other nations, and the numbers in England are not compatible with it not being essentially everywhere already. It’s still right to cut off flights and travel now to slow things down, but the barn door is already wide open.


The biggest question is, instead, is the new English strain (or another similar strain like the one found in South Africa) really 65% more infectious as measured by infections per infected individual?

If that number is greatly exaggerated, then the strain will take a lot longer to get to where it matters, and even when it does the control systems and vaccinations can keep things mostly in check, and we are still on something not too different from the previous track. My guess is that aside from England itself, we could mostly deal with about a 33% more infectious strain given our timetable before it does that much damage.

If the 65% number is accurate, however, we are talking about the strain doubling each week. A dramatic fourth wave is on its way. Right now it is the final week of December. We have to assume the strain is already here. Each infection now is about a million by mid-May, six million by end of May, full herd immunity overshoot and game over by mid-July, minus whatever progress we make in reducing spread between now and then, including through acquired immunity. Which will help somewhat, but likely only buy a few weeks at most. 

One worry I have is that the control system could actively make things worse between now and then, and accelerate the timeline. By the end of January, we should see up to a one third drop in the death rate purely from protecting nursing home residents, and then it will drop further as we protect other elderly people. If as I suspect the control system mostly acts on the death rate, they will use this as a reason to loosen and take more risk, and infection numbers will rise, or not fall the way we would have otherwise expected. 

Then once the new strain arrives, it will be like March and April 2020, where by the time the deaths start spiking it is very late in the game, and there have already been three or more additional doublings. 

The good news is that when this happens, most of our most vulnerable will have had the opportunity for vaccination. Assuming most of them take it, the (need for) hospitalization rate should be dramatically lower, and the IFR should also be dramatically lower if the hospitals don’t collapse. The hope is that with enough of the vulnerable protected, even a gigantic surge in cases might not collapse the system.

That’s the hope. It is basically the best (realistic) case scenario. It seems to be too late to speed up vaccine production much, although I see some reports Joe Biden is considering using the Defense Production Act to do so, in which case why the hell aren’t we doing whatever it takes to get that happening already? Have we considered throwing relatively tiny amounts of money at the problem? Maybe not quite that relatively tiny? No? Oh well. But I digress.  

On the good news front, our tests still mostly seem to work fine for the new strain, although there is some small worry.

There is the concern that the vaccine might not be effective against the new strain, but based on my looking into this, the prior on there being much effect here should not be so high, except insofar as the new strain is more infectious so everything will be somewhat less effective at preventing spread. But if the virus has escaped from the vaccine already while also becoming more infectious, the timeline does not allow us to adjust even if we acted correctly, let alone acting realistically, the best we can hope for is maybe to protect some of the most vulnerable but I do not expect a Biden administration to allow movement fast enough to do that in this scenario. Instead, we’d see completely overwhelmed medical systems across the country, and that would be that. 

On the potentially very good news front is the other big question. Is the new strain less virulent (dangerous) than the old one, and if so by how much?

I don’t think this is a favorite to be true, but I do think there’s a substantial chance (30%?) that it is, and we should investigate. All the news reports say that there’s no reason to expect that the mutation is more dangerous, which is true, but also not the change one would expect to often happen. The real question is whether it is now less dangerous, and for now the answer is we don’t know. If the effect size is big we will presumably figure this out by the end of January. Keeping an eye on England’s IFR will be important. 

There are plausible physical mechanisms that suggest that some of these mutations may have led to less virulence. One piece of evidence that the strain is less virulent is that it is more infectious! Being less virulent causes it to be more infectious, so if the strain is more infectious, there’s a decent chance part of that was caused by less virulence. 

Note that if we do face that scenario in the fourth wave, unless virulence has gone down quite a bit, you now face an even more stark version of what you did preparing for the third wave. 

If we are in this scenario, it is inevitable that there will be a several week period, at a minimum, in which it is super easy to catch Covid-19, with a super infectious strain everywhere, and at a time when there will be no hospitals to help you, and no vaccine that works.

In that scenario, actually protecting yourself becomes vital if you haven’t been infected by the time the climax is approaching. As in essentially not being anywhere near a human outside your bubble, for weeks on end, at least until the hospitals stabilize. 

It also becomes realistic again to worry about our supply chains or civil disorder. I expect everything to hold, but that can’t be assumed. 

Then there’s the other nightmare. When this starts to happen, how will the authorities react?

Benevolent authorities would be responding now by making every attempt to speed up our vaccine efforts, and to prioritize the most vulnerable while we can. But if we had such benevolent authorities, they would have already been doing that. When something goes from super overdetermined to super duper overdetermined, it’s not generally the time to expect people to suddenly come up with the right answer when they didn’t before. Still, there’s some hope that this would happen, as the ‘don’t let it get so bad they sell out of pitchforks’ mechanics kick in. The other problem, as I’ve noted, is that there is not that much room to move faster without much more aggressive disregarding of barriers put in to prevent action, which would cause a ton of cognitive dissonance, and is not Biden’s style.

The question is what our actual, present authorities will do.

Like England, they might go for a full ‘lockdown.’ My assumption is that if they do this, people will end up largely ignoring it, and it won’t be enforced. There’s no will to make real restrictions stick even in blue tribe areas, and red tribe areas would be in open revolt, especially when it comes from a Biden administration. People have had enough, and they’ll have been told the story of how things were supposed to be returning to normal. 

And even when they do that, they’ll still provide enough loopholes that it presumably wouldn’t work even if people didn’t go into open defiance of the rules. 

Still, will they try anyway, doing epic additional economic damage and potentially causing open conflict? I worry about this a lot. 

Thus, I don’t know if one should buy stocks or sell stocks on this, or even if one should buy volatility on this or not. If things crest once more and then burn out, that is not bad for stocks. It’s only bad if we get a dramatic response, which wouldn’t help the problem much but also give us a whole additional set of problems. We need to get ready, now, to do what we can to stop this from happening when the moment arrives, if the moment arrives. Sure, if it worked one could argue in favor, but the math seems rather clear that it won’t do any good. When politicians start trying to make it to next week without taking blame, and attempt to destroy everyone’s lives to do it, we need to find a way to stop them.

Or we could figure out how to make our efforts actually work. It’s not impossible. Is there still time to get our house in order and deal with this head on, if we want to? Hell yeah. But we can’t do it by Sacrificing to the Gods and taking sledgehammers to everything people like doing. We can’t even do it via doing that and being willing to shut down economically important activity, not for long enough to work. I’d be pleasantly surprised if we could even stabilize growth rates that way, and it’s completely unsustainable.

What we could do is prepare a testing regime now. Have that in place a few months from now, for real, and do the kind of testing on everyone that some universities do with their students. If we took all the regulatory gloves off, my guess is we wouldn’t even have to subsidize to get there on time. Add in proper focus on Vitamin D, airflow, outdoor activity and so on. We could still make it, and it would be an essentially free action. 

We could probably start this on January 20 and still make it. 

To be clear: We won’t attempt to do this, and it won’t happen. But it’s important to note that we still could, in at least some sense, still win, while also noting that we will lose. You never know. Maybe someone, somewhere, is actually listening.

In summary, I am attempting here to do now what I failed to do in December or January, which is to actually model what happens next based on exponential growth and realistic reactions by authorities. 

My guess is that the English strain is probably sufficiently infectious to get there before enough vaccinations can happen to let realistic measures contain the pandemic. Right now I’m giving the strain something like a 70% chance to be sufficiently infectious, and if it is, I don’t see a way around this outcome. 

This has counterintuitive implications, both for public policy and for individuals. As always, one’s approach to the pandemic must be to either succeed if one can do so at a cost worth paying, or fail gracefully if one cannot succeed. Thus, one could plausibly either make the case for being even more careful in response, or to folding one’s hand entirely. You can raise, or you can fold, but you can’t play passive and call all bets and hope to go to showdown.

It’s also important to figure out whether the new strain is less virulent than the old one, and if so to what extent, since that could change the math on sensible courses of action quite a bit. I haven’t fully wrapped my head around the implications, and I doubt many others have either. Simply saying it is “good news” does not begin to cover how this changes correct actions.

Let’s actually engage with the physical situation and model out what happens, and learn from last time out’s mistakes.

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27 Responses to Covid 12/24: We’re F***ed, It’s Over

  1. I’ve seen reports that CT values for the new variant are coming in on average at 2 less than for previous strains. If that’s true, if viral loads with this are 4 times higher than previously then I’d expect that hosts can infect someone with an interaction 1/4th as long and that this would cause somewhere around the rise in infectiousness we’re seeing. It’s not clear what implications this has for symptoms since hospitalizations tend to occur a week or more after symptom onset when viral loads are substantially reduced from peak. But that’s my current best guess as to the mechanism by which it’s more infectious.

  2. Hareeb al-Saq says:

    If everything stayed the same with current COVID/behavior/testing except it went 100% asymptomatic, how much of the UK graph could be explained? Maybe 25%? So much transmission now is pre-symptomatic or from completely asymptomatic cases that reduced symptomatic percentage on the normal timelines can’t cause too much of a transmission increase, and that gets even smaller through the infection cycle- e.g. killing or not killing people who’ve known they’re sick for awhile is almost irrelevant to transmission. The new strain may be less virulent by luck, but it looks almost impossible to me that very much of its increased spread could be for that reason.

  3. Doug S. says:

    From the “creative ideas that will never get implemented in the real world” department:

    Put a nationwide $20 per gallon tax on gasoline for the duration of the pandemic. That’ll shut down non-essential travel real good! (Or maybe you’d get more problems when people resort to carpooling. Policy is hard.)

  4. myst_05 says:

    A bit of math: if the R0 of the new virus is 50% higher, we need (1-1/1.5)=33% less people without immunity to go back to R0. As per covid19-projections we are now at R0 of 1.0 with 60 million infected/268 million without immunity. So with the new strain we would need 150 million people in the US infected or 2.5 times more than with the current strain. Sounds like a nightmare indeed when combined with pandemic fatigue, which is now so bad that even countries like South Korea or Japan are starting to struggle.

    Hopefully we could get to 150 million vaccinated+immune before the new strain reaches the final parts of the exponential spiral.

  5. Dax Diamond says:

    The graph shows that the new variant went from 1% to 11% of new infections in about 3 weeks. 1.7 with a 4.5 exponent is about 11. 21/4.5 = 4.7 days (close to 5). Seems like that tells us what “70% more infectious” means.

  6. nostalgebraist says:

    I’m confused by your pessimism about England’s Tier 4 restrictions:

    So basically, if you’re outside where it’s safe, they’ll harass you and maybe worse. Whereas if you stay inside, technically it’s not allowed but in practice it’s a lot less likely anything happens to you, unless the anything in question is ‘you catch Covid-19.’ The rules are porous enough that they aren’t enforceable against the things that are risky but enforceable enough to shut down the relatively safe actions that keep people sane. And with weird exceptions for remarkably large indoor gatherings for certain events that are textbook superspreaders.

    All of which is what our model expects to see, and none of which seems likely to be remotely sufficient if the new strain is as infectious as they estimate.

    Tier 4’s bundle of restrictions is almost identical to those from England’s “second lockdown” in Novermber. (See e.g. here.) But you write as though you believe the “second lockdown” was impactful:

    […] the context of England being under lockdown conditions that had previously turned the tide […]

    How effective are these kind of measures at controlling things (a) before the new strain and (b) with the new strain?

    This heavily discussed paper from Dec 23 addresses question (b), using the same model the authors previously applied to question (a) in this paper. These papers are worth reading and I won’t attempt to summarize them, but some relevant points:

    – The authors argued for the “second lockdown” in the 2nd linked paper on the basis of its projected impacts on mobility, thus R, thus etc.
    – The 2nd linked paper was later updated with data from November, showing that their model did quite well at predicting the effect on mobility, R, etc.
    – The 1st linked paper (on new strain) approximates Tier 4 as being equivalent to “second lockdown” in its effects
    – The 1st linked paper (on new strain) is worth reading in its entirety as it provides some (provisional) quantitative backing to intuitions about the impact of various measures (Tier 4 / Tier 4 + school closures / Tier 4 + school closures + XYZ amount of vaccination)

    • According to that paper, almost all the heavy lifting is being done by vaccination, and their only “good” scenario is getting to 10x the current vaccination speed. Table 1 shows that Tier 4 is only marginally different. They don’t directly report a prediction for infections, but using estimated deaths and a 0.25% IFR, 118k deaths is 47M infections. The entire population of England is like 56M. Tier 4 + schools closed. reduces that to 40M or ~73% of population infected. And those are both just through the first half of 2020. Infections would obviously keep going a bit beyond that, and it’s in addition to whoever’s already been infected. And they’re even overestimating the effectiveness of vaccination because they assume the vaccine works on day 1 when it’s likely effectively lagged by at least a week.

    • TheZvi says:

      Family holiday events beckon but I looked a bit. I hadn’t seen this before and it has a bunch of interesting stuff in there. It also seems to propose a bunch of physical mechanisms that seem odd to me, for reasons I don’t understand.

      I think Hareeb has the basically correct take here on the second paper, which is that Tier 4 isn’t enough and we lose anyway if the calculations are correct (which they may not be). That what is being proposed are lockdown scenarios that stretch out everything for longer, and perhaps make the peak hospital crisis somewhat better and/or allow for more vaccinations versus doing less, but still end in full overshoots of herd immunity. Which matches what I think OP was saying – or at least what it was going for.

      The basic idea is: England’s tier 4 is harsh. It does have real effect – the alternative scenario was losing to the old virus, not only the new one. The problem is that it’s already past the point where people are willing to follow the restrictions for an extended period, so trying to further tighten other than via school closings will only drive people to do disguised or defiant behaviors and backfire, if it hasn’t already, unless England has will to enforce restrictions at the barrel of a gun for real. To do better they’ll have to be *smarter* rather than just sacrificing harder, and if they had that ability why didn’t they already do that?

      Or more essentially: You start with some baseline from old virus (e.g. R0=3 or something, varies by region and conditions). You then get help from voluntary action, and can boost somewhat through restrictions. A Tier 4 regime seems good enough at least short term to get this slightly under 1, and alllow some progress, but it’s nowhere close to being able to survive the move to the new strain if it’s 50%+ easier to spread, and they’re out of options unless they will do the things Western countries have decided not to do (e.g. allow less regulated testing, vaccinate with proper urgency, actually enforce quarantines and contact tracing, etc etc).

  7. cgln says:

    Merry Christmas to those who celebrate it!

    I disagree strongly that an auction is the theoretically most-efficient method of allocation:

    1. If we define most-efficient as “cheapest to allocate,” then the winner seems like it’d be some decision by fiat. Markets have costs and choices, and costs and choices are bad. Better to waste some administrator’s brainpower, than waste everyone’s brainpower along with imposing market-inherent transaction costs.

    2. If we define most-efficient as “leading to the best theoretical result,” then the winner is still not an auction-system:

    a. On a societal level, we want to get herd immunity in as many places as possible. This would suggest distributing vaccines by location. First, vaccinate everyone in the West (or some other arbitrary region) whether they want to or not. Then everyone in the South, then Midwest, and so on, in some arbitrary order. Probably fractally as well, by counties and by regions of counties. (Compare to an auction, which would be random-ish geographically, and lower R0 in various places without going all the way.)

    b. People’s desires for the vaccine don’t match up with the utility they’d get from it. For example, a health-paranoid person who works from home and takes as many precautions as possible (the type of person who would keep wearing a mask and socially-distancing even after getting vaccinated), would value the vaccine very highly, even though the expected change to their daily lives is minuscule. But the owner of a busy hair salon (the type of person who doesn’t consistently wear a mask even when interacting with customers) probably wouldn’t value the vaccine much or at all, but would certainly get more mileage out of it. Choices are bad and in an auction, many are guaranteed to choose poorly.

    c. There are tons of externalities. Even if you think you would get more utility from vaccination than another person, and if this belief is correct, your expected utility also hinges on this same calculation on the part of others. Ultimately, this is a kind of coordination problem. Government fiat is traditionally one of the solutions to coordination problems.

    What do you see an auction system doing better than some allocation-by-fiat (like lotteries, prioritization-by-age, or geographical distribution), on an individual or collective level, out of curiosity?

    (How do you see an auction performing differently than allocation-by-political-pull?)

    • TheZvi says:

      Putting a note here that given the urgency of other issues, and the implausibility of actually convincing the unconvinced on such subjects, and the Demon Thread dangers thereof, that I’m not going to engage with any arguments about vaccine allocation, but people are welcome to post them and reply to each other. To extent that I respond to such comments, it will be in future weeks of updates, but I am going to attempt to not even do that.

    • Glen Raphael says:

      Allocation-by-fiat is what we’re doing NOW and it resulted in lots of unused doses sitting around in refrigerators.

      A big benefit I see from allocation-by-money is that it allows coordinated GROUPS of individuals to all get vaccinated together at the same time thereby maximizing their GROUP utility. For instance, the cast and crew of a television show could all get vaccinated for a tiny fraction of what they’re continually spending now on tests and PPE and extra cleaning staff and extra space, after which the whole production (and the whole industry) could basically resume their prior business-as-usual. Vaccinating a RANDOM SAMPLE of the cast-and-crew doesn’t accomplish that goal nor does vaccinating only the HIGHEST MEDICAL RISK fraction of the cast-and-crew – you need to do the whole group.

      And a group like that is motivated to get the doses out ASAP so they’re going to hire extra people to work extra shifts or extra hours delivering doses around the clock until the job is DONE because time is money and they need it done NOW.

      An obvious compromise option would be to let companies like Pfizer sell SOME of their stored doses via a market. Every little bit counts! Tell them that as long as they have met all existing orders and keep a safety buffer amount of X doses to handle new orders they can sell the rest on the market. Or just let them sell, say, 20% and see how it goes from there.

    • Anonymous says:

      “b. People’s desires for the vaccine don’t match up with the utility they’d get from it.”

      Beware the “utilitarian” who defines other people’s “utility” against their will.

      “There are tons of externalities.”

      True, but most of those can be mitigated by making the vaccine more available to people who want them more. We don’t need to make the virus extinct, only to mitigate the damage it does to people.

  8. Chris says:

    More in “What Did You Expect Would Happen?” news:
    “Hospital Workers Start to ‘Turn Against Each Other’ to Get Vaccine”

    • Sjur Kristoffer Dyrkolbotn says:

      It seems to me that CellBioGuy is probably correct regarding the appropriate interpretation of reported figures on increased infectiousness of new variants. Surely, it is not relevant what the researchers *intend* it to mean, or what they *think* it means. What matters is where and when they got their data. If I and CellBioGuy are correct, you would expect the following basic pattern: when Rt is high during data collection you estimate a (much) higher % increase than if Rt is lower. Not yet falsified, to my knowledge, despite several attempts (Sweden and Holland). Moreover, *all* your nice intuitive alternative explanations of what it could mean are consistent with our hypothesis, as far as I can tell. Frankly, assuming a fixed percentage independent of Rt seems insane to me.

  9. Anonymous Londoner says:

    Some thoughts on the new strain and the local response from someone in one of the worst-hit parts of London. I haven’t done the detailed work analysing numbers I should have done because being locked down with a baby and a toddler, so this blog is a literal lifeline.
    1) The COVID tracker app at covid.joinzoe.com (which works by getting app users to self-report symptoms daily in exchange for priority access to testing) is reporting a noticeably slower increase in symptomatic COVID than the government is reporting on positive tests (roughly 1.5x since the trough rather than 2.5x, with the difference more dramatic in my part of London). My initial reaction is that this is strong circumstantial evidence that the new strain is less virulent (because a higher percentage of cases are asymptomatic).
    2) I am out twice a day to walk the dog, and I have not encountered any attempts to enforce the 2nd or current lockdowns outdoors. The zeitgeist in London is that it is impossible to catch COVID outdoors – before the news came about the new strain there was <10% outdoor mask wearing and essentially zero attempts to socially distance outdoors (mask wearing in shops and on public transport is close to 100%, and enforced – this isn't just an anti-mask culture). Since the news arrived, there is about 20% outdoor mask wearing and about half the people you meet will avoid passing within 6 feet if it is convenient to do so.
    3) Anecdotally, everyone in my social circle (admittedly dominated by people who work in healthcare or from home) is complying with the rules. London has generally had better compliance with restrictions than the rest of the country, going back to the first wave.
    4) In previous lockdowns, the main driver of enforcement against minor breaches has been neighbours snitching on people who socialise indoors at home. Prominent politicians and civil servants who misbehave in this way generally get punished (although Dominic Cummings notoriously didn't).
    5) I am registering my confusion that the trough in hospitalisations in the UK is around the same time as the trough in positive tests, rather than lagging it. (See coronavirus.data.gov.uk for official data, the case counts are consistent with the graph in the main post).

  10. Dax Diamond says:

    Experts now think the new variant is between 50% and 74% more transmissible than other dominant strains, according to a study by the Center for Mathematical Modeling and Infectious Diseases (CMMID) that has not yet been peer-reviewed. The WHO estimates this would tack on 0.4 to the basic reproductive number R, which dictates how many people each infected person would spread the virus to.

    Here’s the link: https://www.livescience.com/uk-variant-coronavirus-faq.html

  11. Erasmus says:

    I haven’t visited this blog in a while, but if anyone has any views, I would be interested, if anyone cares to condescend to respond to my questions, since both Zvi and the readers seem to have deep knowledge in at least one area, which I take to be statistics (and not medicine).

    1. Now that the vaccine triage numbers are out, it seems there are 103 million Americans classed as either health care or essential workers. These brave folks have been out there since March. Question: How could anyone who supported the (non-lockdown) lockdown approach (contrast: Wuhan in February 2020, a true lockdown) have thought that you could accomplish much by semi-isolating 2/3ds of the population, and letting the rest roam free?

    2. Isn’t R-0 a speculative construct? Meaning, like a 5-year or 10-year DCF (discounted cash flow)
    deck created by Wharton school graduates at JPM or Goldman? I spent my life with these. They have their uses, but no one who actually ran a company thought of them as anything other than….speculation. I’m not saying speculating about the R-0 value isn’t a useful mental exercise, but do we really need to talk about it like it’s a fact? In business, we all understood that statistics have a limited usefulness, depending on the reliability of the inputs. GIGO. How reliable do you folks think the inputs are? Yes, I know they’re as good as we can get — but that doesn’t mean they are actually reliable?

    3. I get the sense from the way Zvi writes, and readers respond, that you folks think the goal here is or must be or should be,
    “defeating” or “eliminating” the virus. Really? That train left the station sometime last Spring. It is clearly not possible. We will learn to live with it, and, yes, some of us will die with it. Tough.

    4. So, this new Covid variant is identified. You do know the UK science advisory group was much less concerned about it than the politicians? And that its been around since at least September? And that (so far) it doesn’t seem to be associated with more deaths or severe cases? is it a surprise to ANYONE a virus mutates to become more transmissible? Thats Virology 101. Why the panic?

    5. The panic — which you can sense from Zvi’s post — is because of the healthcare system. So, let’s take a step backwards. All Western countries decided around 1970 that widespread outbreaks of infectious diseases were a thing of the past, due to antibiotics etc? Remember how the medical establishment wouldn’t believe HIV was a new transmissible infection for a few years (and Dr Fauci was there) … I don’t blame them, we thought it was all over. We thought it was going to be all about non-transmissible chronic things like heart disease, diabetes, cancer etc. So — asa society — what did we do? We reduced the number of beds. I’ve seen statistics for the UK that say the beds per whatever metric (I forget, 100 k maybe?) when from 10 to 2. I would guess something like that’s true for the US, though given our state by state system, this kind of fact takes work to develop.
    So now, despite the warning in March 2020, we still have the same number of ICU beds and ICU support staff (you may recall there was a lot — I mean hundreds of millions — spent on extra capacity in NY, not just the Navy vessel, I mean the Javits Center and the US Tennis property).
    THIS should be the point. We had the warning. We didn’t prepare — the SECOND time. Because the “lockdowns” are really all about the government not wanting there to be pictures of corpses on the sidewalks. (Btw, I live in Manhattan, opposite a major hospital — they were not, as an institution, “overwhelmed” in March. Which isn’t to say the individual doctors and nurses weren’t overwhelmed personally about their jobs.)

    Well, I’ll be surprised if anyone cares to respond. But, if anyone does, thank you.

    • TheZvi says:

      1. They were not thinking in such terms. They were trying to look responsible and avoid blame with time horizons in weeks, and were looking to avoid full collapse scenarios, and worry about next month next month. That said, if we think initial R0 was something like 3, it’s not unreasonable to think one could get it under 1 in such a way, and certainly wasn’t an unreasonable thing to hope for in March – you can combine various countermeasures and each helps.

      2. Both yes and no, less arbitrary than DCF models. Obviously R0 moves around and is only meaningful based on a given place and time and set of assumed conditions, but knowing that number matters a lot and I don’t know how to think about things without the concept – you can use different words but the concept is needed. Talking about ‘current R0 at location X’ seems very useful and non-arbitrary, as do marginal changes in it, as does talking about the initial ‘in general’ value.

      3. That is certainly one goal, if we could do it, but I’ve spent a lot of words saying that we clearly are unwilling to do what it takes to do that any time soon and thus need to consider our plans in that light, including potentially ‘learning to live with it’ more broadly if the alternatives available are worse. That said, I think it’s worth pointing out that we still *could* do suppression at remarkably low cost if we were wanted it.

      4. Don’t panic! In large friendly letters, on the cover. WFIO comes from an expression used by start-ups, which says that it’s time to admit the business has failed. That’s not panic, that’s facing reality. Your life is not over, but if you keep wasting it on this venture that can’t succeed, what’s the point? Very similar to your point #3, actually. So the response should change quite a bit, but panic does not seem useful. And I don’t think I said, AT ALL, that this development was shocking or unlikely, only that it had happened. Agree fully that it was reasonably likely to happen eventually, but it almost didn’t , as the vaccine almost got there in time, and still might if the increased spread is lower than we think (e.g. my estimate was if it’s only 33% more infectious we probably win the race).

      5. Agree that our failures to expand capacity are one of our many systemic failures, and I think I’ve been clear on that. In my model the main barrier is that we’ve made it illegal and expensive to do things and to build things, and medicine is super regulated, and we also didn’t care enough to even try. I don’t think I put this at the top of my list, and reversing it would have actually been really hard given the regulatory issues they’d have to reverse (e.g. I think taking out FDA issues would be a much easier path to winning), but it’s a reasonably large failure.

  12. Erasmus says:

    Does I matter if its 3x more infectious — if, as AstraZeneca has now said — the vaccine is equally effective against it? And that means the other vaccines are likely to be? Can we pause before getting hysterical and saying “we’re f**ked”? And what virologist would have be there wouldn’t be a
    mutant strains a year into the pandemic? Were only “f***ed” if you harbored the irrational hope the virus would be eliminated…..If that was the hope, yes…. But, really?

    • Anonymous says:

      Depends on how fast you can get the vaccine to the people who most want to be vaccinated. If the new variant really is this infectious, we’re looking at fast exponential spread.

    • TheZvi says:

      6. It matters up and until the AZ vaccine (in combination with the others) is actually administered in sufficient quantities to overcome this increased infectiousness. If it was truly 3x (e.g. 200% more infections per person) then that matters a lot because it will spread very, very quickly and overwhelm things everywhere long before the vaccine can be used in much bulk, so we’d want to race to protect the most vulnerable and that would be that. Of course, we’re looking at much less than that.

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